This genus has one species, influenza A virus. Wild aquatic birds are the natural hosts for a large variety of influenza A. Occasionally, viruses are transmitted to other species and may then cause devastating outbreaks in domestic poultry or give rise to human influenza pandemics. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. The influenza A virus can be subdivided into different serotypes based on the antibody response to these viruses. The serotypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are:
*H1N1, which caused Spanish flu in 1918, and the 2009 flu pandemic
*H2N2, which caused Asian Flu in 1957
*H3N2, which caused Hong Kong Flu in 1968
*H5N1, a current pandemic threat
*H7N7, which has unusual zoonotic potential
*H1N2, endemic in humans and pigs
*H9N2
*H7N2
*H7N3
*H10N7
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